Ceramides, explained
The skin’s natural “mortar”. Why ceramides matter more as we get older, and how to choose a moisturiser that really helps dry skin.
Good evidence for dry skin
What they do
Ceramides are fats that make up much of the skin’s outer barrier, holding skin cells together like mortar between bricks. A strong barrier keeps moisture in and irritants out.
Why they suit skin over 40
Skin makes fewer ceramides with age, and dryness becomes very common later in life. Ceramide moisturisers help repair the barrier, so skin feels less tight, flaky and sensitive. They also help skin cope with retinoids and acids.
What to look for
- Ceramide NP, AP, EOP or “ceramide complex” on the ingredients list.
- Formulas that also contain cholesterol and fatty acids, which work together with ceramides.
- Korean barrier creams often pair ceramides with centella or panthenol.
How to use them
- In your moisturiser, morning and night.
- Especially helpful on retinoid nights and in winter.
- Suitable for sensitive and eczema-prone skin.
What the research shows
In a split-site, double-blind, randomised trial of 24 adults with dry skin (average age about 55), a ceramide moisturiser improved hydration and barrier function for up to 24 hours after one use. After 28 days of twice-daily use, it outperformed a standard moisturiser on hydration, barrier function and skin pH.
Lueangarun and colleagues, Dermatologic Therapy [1]
In two groups of 21 people over 60 with dry skin, an emollient containing urea, ceramide NP and lactate hydrated skin more, and for longer, than a comparison emollient without them.
Danby and colleagues, Skin Pharmacology and Physiology, 2016 [2]
Good to know
Are ceramides good for skin over 40?
Yes. Skin makes fewer ceramides with age, so a ceramide moisturiser helps dry, tight or sensitive skin.
Can I use ceramides with retinol?
Yes. Ceramides help reduce the dryness and irritation retinoids can cause.
Are ceramides vegan?
Most skincare ceramides are made in the lab, so they’re usually vegan, but check the brand.
Sources
- Lueangarun S et al. The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment. Dermatol Ther.
- Danby SG et al. The effect of an emollient containing urea, ceramide NP, and lactate on skin barrier structure and function in older people with dry skin. Skin Pharmacol Physiol. 2016;29(3):135-47.
This page is general information, not medical advice. Last updated 30 October 2026.